Gastroenterology

Celiac Disease


Introduction: It is a chronic, autoimmune disease that affects approximately 1 in 200 individuals in the population. It is induced by the ingestion of gluten, contained in wheat, barley and rye in genetically susceptible individuals.
About the exam: This study allows to determine if you have the genetic information necessary to develop the disease. For this, the presence of genotypes DQ2 and DQ8 is analyzed. In case none of these genotypes are present, the disease can not be developed (High exclusion value). While if the DQ2 and / or DQ8 genotype is carried, it is genetically susceptible, although not necessarily the disease will develop. Genes or alleles analized: HLA: DQ2 DQ8 Technique used: Fragments & PCR Sample type: Whole blood (EDTA tube), 2.5 mL // Mouth swab, 3 brushes // germinal DNA, 50uL, concentration 10ng / uL Results delivered in: 10 business days In case you have any questions, get in touch.




Lactose intolerance


Introduction: Lactose intolerance usually causes upset stomach, bloating or diarrhea soon after digesting lactose (lactose is a type of sugar present in milk and some products). There are three types of lactose intolerance: 1) Lactase congenital deficiency (Genetic, from birth, not recoverable), 2) Primary lactase deficiency (Genetic, progressive, non-recoverable), 3) Lactose secondary deficiency (it is not genetic , it is temporary and recoverable). About the exam: LabGenia has developed to diagnose:

  • Congenital lactose intolerance study of the c.4170T> A polymorphism (Y1390X) in the LCT gene.
  • Intolerance to primary lactose the study of LCT polymorphisms T13910C and LCT A22018G in the MCM6 gene. The genetic diagnosis has the advantage of not being invasive, the sample is taken by mouth swab of the individual, without causing symptoms, and can be performed before the appearance of them.
Genes or alleles analized: LCT, c.4170T>A (Y1390X) MCM6, T13910C, A22018G Technique used: Sanger Sample type: Whole blood (EDTA tube), 2.5 mL // Mouth swab, 3 brushes // germinal DNA, 50uL, concentration 10ng / uL Results delivered in: 10 business days In case you have any questions, get in touch.




Nutrigenomics


Introduction: The Nutrigenomic Genetic Profile allows nutrition recommendations, lifestyle habits, and exercises to be adapted exclusively to their needs. About the exam: In this study the following genes are studied with their respective incidences on diet: ADH1C (Alcohol metabolism), APOE (lipid metabolism, cholesterol transport), CYP1A2 (Caffeine metabolism), RCT (blood pressure regulation; muscle performance, lipid and glucose levels, blood sodium levels), TCF7L2 (glucose metabolism, risk of type 2 diabetes), FTO (obesity, type 2 diabetes, satiety, lipid metabolism), GSTM1 detoxifying and antioxidant), GSTT1 (metabolism of vitamin C), HLA (gluten intolerance), LCT (lactose intolerance), MTHFR (folic acid metabolism), NOS3 (omega-3 fat metabolism), PPARG- (Metabolism of lipids, glucose metabolism, type 2 diabetes, maintenance of BMI), ADRB2 (Obesity, mobilization of fat, "rebound" effect), VDR (Metabolism of vitamin D), SOD2 (detoxifying and antioxidant capacity). Genes or alleles analized: ADH1C, APOE, CYP1A2, ECA, TCF7L2, FTO, GSTM1, GSTT1, HLA-DQ2 e DQ8, LCT, MTHFR, NOS3, PPARG, ADRB2, VDR, SOD2 Technique used: -- Sample type: Mouth swab, 3 brushes // germinal DNA, 50uL, concentration 10ng / uL Results delivered in: 40 business days In case you have any questions, get in touch.





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